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Rabbit Anti-GATA2 + GATA3 antibody
Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.
Function:
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.
Subcellular Location:
Nucleus.
Tissue Specificity:
Endothelial cells.
DISEASE:
Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.
Similarity:
Contains 2 GATA-type zinc fingers.
SWISS:
P23769
Gene ID:
2624
2625
Database links:
Entrez Gene: 2624 Human
Entrez Gene: 2625 Human
Entrez Gene: 14461 Mouse
Entrez Gene: 14462 Mouse
Entrez Gene: 25159 Rat
Entrez Gene: 85471 Rat
Omim: 13164 Human
Omim: 137295 Human
SwissProt: P23769 Human
SwissProt: P23771 Human
SwissProt: O09100 Mouse
SwissProt: P23772 Mouse
SwissProt: Q924Y4 Rat
Unigene: 367725 Human
Unigene: 524134 Human
Unigene: 313866 Mouse
Unigene: 34322 Rat
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