TTBK1 (tau tubulin kinase 1), also known as BDTK (brain-derived tau kinase), is a 1,321 amino acid protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of tubulin dynamics. Two isoforms of TTBK1 are expressed due to alternative splicing events.
Function:
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.
Similarity:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Contains 1 protein kinase domain.
SWISS:
Q5TCY1
Gene ID:
84630
Database links:
Entrez Gene: 84630 Human
Entrez Gene: 106763 Mouse
SwissProt: Q5TCY1 Human
SwissProt: Q6PCN3 Mouse
Unigene: 485436 Human
Unigene: 297613 Mouse
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