HRASLS3 specifically catalyzes the release of fatty acids from phospholipids in adipose tissue and also has a weak lysophospholipase activity. It is a tumor suppressor that may be involved in interferon-dependent cell death.
Function:
Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N-and O-acylation activity is hardly detectable. Also has weak lysophospholipase activity.
Subunit:
Interacts with PPP2R1A; this interaction might decrease PP2A activity.
Subcellular Location:
Membrane; Single-pass membrane protein (Potential). Cytoplasm. Cytoplasm, perinuclear region.
Tissue Specificity:
Ubiquitously expressed in normal tissues but down-regulated in primary carcinomas or in many cell lines derived from tumors. Highly expressed in white adipose tissue and in adipocytes. Expressed at lower levels in brown adipose tissue.
Similarity:
Belongs to the H-rev107 family.
SWISS:
P53816
Gene ID:
225845
Database links:
Entrez Gene: 11145 Human
Entrez Gene: 225845 Mouse
Omim: 613867 Human
SwissProt: P53816 Human
SwissProt: Q8R3U1 Mouse
Unigene: 502775 Human
Unigene: 274810 Mouse
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