Rabbit Anti-CES2 antibody | Sunlong Medical

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Carboxylesterase 2 (intestine, liver); Carboxylesterase 2; CE-2; CES2; CES2A1; Cocaine esterase; EC 3.1.1.1; EST2_HUMAN; hCE-2; ICE; Iintestinal carboxylesterase liver carboxylesterase 2; Intestinal carboxylesterase; liver carboxylesterase-2; Methylumbell

Cat:

SL20183R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human CES2:251-350/559

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.

Subcellular Location:
Endoplasmic reticulum lumen.

Tissue Specificity:
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the type-B carboxylesterase/lipase family.

SWISS:
O00748

Gene ID:
8824

Database links:

Entrez Gene: 8824 Human

Omim: 605278 Human

SwissProt: O00748 Human

Unigene: 282975 Human

羧酸酯酶主要位于肝、其他组织及细胞胞液、线粒体和内质网。是一种多聚蛋白，主要催化酯、硫酸酯和酰胺的水解。

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