This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015].
Function:
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
Subunit:
Interacts with NGL1.
Subcellular Location:
Cell membrane. Lipid-anchor, GPI-anchor, Extracellular side.
Tissue Specificity:
Highly expressed in the thalamus, with very low expression, if any, in other tissues.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.
SWISS:
Q9Y2I2
Gene ID:
22854
Database links:
Entrez Gene: 787473 Cow
Entrez Gene: 490132 Dog
Entrez Gene: 100714441 Guinea pig
Entrez Gene: 100060362 Horse
Entrez Gene: 22854 Human
Entrez Gene: 80883 Mouse
Entrez Gene: 100152257 Pig
Entrez Gene: 100341879 Rabbit
Entrez Gene: 295382 Rat
Omim: 608818 Human
SwissProt: Q9Y2I2 Human
SwissProt: Q8R4G0 Mouse
Unigene: 657434 Human
Unigene: 732535 Human
Unigene: 39262 Mouse
Unigene: 162628 Rat
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