Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNX11 (Sorting nexin-11) is a 270 amino acid protein that contains one PX domain and is likely involved in several stages of intracellular trafficking.
Function:
May be involved in several stages of intracellular trafficking.
Subcellular Location:
Membrane.
Similarity:
Belongs to the sorting nexin family.
Contains 1 PX (phox homology) domain.
SWISS:
Q9Y5W9
Gene ID:
29916
Database links:
Entrez Gene: 29916 Human
Entrez Gene: 74479 Mouse
SwissProt: Q9Y5W9 Human
SwissProt: Q91WL6 Mouse
Unigene: 15827 Human
Unigene: 270781 Mouse
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