Rabbit Anti-Neogenin antibody

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NGN; Neo1; Neo 1; Neogenin; NEO1_HUMAN.

Cat:

SL20422R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Neogenin:1001-1100/1461<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a cell surface protein that is a memberof the immunoglobulin superfamily. The encoded protein consists offour N-terminal immunoglobulin-like domains, six fibronectin typeIII domains, a transmembrane domain and a SLCterminal internaldomain that shares homology with the tumor suppressor candidategene DCC. This protein may be involved in cell growth anddifferentiation and in cell-cell adhesion. Defects in this gene areassociated with cell proliferation in certain cancers. Alternatesplicing results in multiple transcript variants. [provided byRefSeq, Feb 2010].

Function:
Neogenin is one of several netrin-binding proteins. Neogenin functions as an Repulsive Guidance Molecule (RGM) receptor; RGM is implicated in axonal guidance and neural tube closure.

Subunit:
Interacts with RGMA. Interacts with MYO10

Subcellular Location:
Cell membrane; Single-pass type I membraneprotein.

Tissue Specificity:
Widely expressed and also in cancer celllines.

Similarity:
Belongs to the immunoglobulin superfamily. DCC family.
Contains 6 fibronectin type-III domains.
Contains 4 Ig-like C2-type (immunoglobulin-like)domains.

SWISS:
Q92859

Gene ID:
4756

Database links:

Entrez Gene: 4756 Human

Entrez Gene: 3607 Mouse

Entrez Gene: 81735 Rat

Omim: 601907 Human

SwissProt: Q92859 Human

SwissProt: P97798 Mouse

SwissProt: P97603 Rat

Unigene: 388613 Human

Unigene: 42249 Mouse

Unigene: 10667 Rat

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