May play a role in cell proliferation, differentiation and death.High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
Function:
Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.
Subunit:
Interacts (via its SLCterminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16
Subcellular Location:
Cytoplasm. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.
Tissue Specificity:
High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.
Post-translational modifications:
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
Similarity:
Belongs to the GTP1/OBG family.
Contains 1 G (guanine nucleotide-binding) domain.
SWISS:
Q9Y295
Gene ID:
4733
Database links:
Entrez Gene: 4733 Human
Entrez Gene: 13494 Mouse
Entrez Gene: 305470 Rat
Omim: 603952 Human
SwissProt: Q9Y295 Human
SwissProt: P32233 Mouse
SwissProt: Q5I0F0 Rat
Unigene: 115242 Human
Unigene: 3250 Mouse
Unigene: 102143 Rat
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