Home
>
Product
>
Antibody
>
Rabbit Anti-DAL1/ EPB41L3 antibody
EPB41L3 is an actin-binding protein originally identified as a molecule whose expression is down-regulated in lung adenocarcinoma. EPB41L3 is a member of the protein 4.1 superfamily, which encompasses structural proteins that play important roles in membrane processes via interactions with actin, spectrin, and the cytoplasmic domains of integral membrane proteins. The gene for EPB41L3 is thought to function as a tumor suppressor and localizes within chromosomal region 18p11.3, which is affected by loss of heterozygosity (LOH) in various adult tumors.
Function:
Critical growth regulator in the pathogenesis of meningiomas.
Subunit:
Interacts with CADM1.
Subcellular Location:
Cytoplasm, cytoskeleton
Tissue Specificity:
Expressed at high levels in brain, with lower levels in kidney, intestine, and testis.
Similarity:
ontains 1 FERM domain.
SWISS:
Q9Y2J2
Gene ID:
23136
Database links:
Entrez Gene: 23136 Human
Entrez Gene: 13823 Mouse
Entrez Gene: 116724 Rat
Omim: 605331 Human
SwissProt: Q9Y2J2 Human
SwissProt: Q9WV92 Mouse
Unigene: 213394 Human
Unigene: 131135 Mouse
|
|