Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the RecA family. RAD51 subfamily.
SWISS:
O43543
Gene ID:
7516
Database links:
Entrez Gene: 7516 Human
Entrez Gene: 57434 Mouse
Entrez Gene: 499966 Rat
Omim: 600375 Human
SwissProt: O43543 Human
SwissProt: Q9CX47 Mouse
Unigene: 647093 Human
Unigene: 143767 Mouse
Unigene: 8224 Rat
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