The collapsin response mediator protein (CRMP) family of five cytosolic phosphoproteins are highly expressed throughout brain development. The functions of CRMPs encompass signal transduction in developmental guidance cues as well as multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, CRMPs remain expressed in structures that retain their capacity for differentiation and plasticity. The expression of CRMPs is altered in neurodegenerative diseases, and these proteins may have a role in the physiopathology of the adult nervous system.
Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Subunit:
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity).
Subcellular Location:
Cytoplasmic. Cell projection, growth cone (By similarity). Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
Post-translational modifications:
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Similarity:
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
SWISS:
Q14195
Gene ID:
369
Database links:
Entrez Gene: 369 Human
Entrez Gene: 2248 Mouse
Entrez Gene: 25418 Rat
Omim: 601168 Human
SwissProt: Q14195 Human
SwissProt: Q62188 Mouse
SwissProt: Q62952 Rat
Unigene: 519659 Human
Unigene: 428551 Mouse
Unigene: 836 Mouse
Unigene: 93365 Rat
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