The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008]
Function:
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion.
Tissue Specificity:
Ubiquitously expressed in various hematopoietic cells.
Post-translational modifications:
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment.
Similarity:
Contains 3 EF-hand domains.
SWISS:
O14950
Gene ID:
103910
Database links:
Entrez Gene: 614055 Cow
Entrez Gene: 103910 Human
Entrez Gene: 67938 Mouse
Entrez Gene: 50685 Rat
Omim: 609211 Human
SwissProt: A4IF97 Cow
SwissProt: O14950 Human
SwissProt: Q3THE2 Mouse
SwissProt: P18666 Rat
Unigene: 190086 Human
Unigene: 464472 Human
Unigene: 261329 Mouse
Unigene: 485011 Mouse
Unigene: 214633 Rat
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