This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq].
Function:
Cytokine that contributes to the inflammatory response in vivo.
Subcellular Location:
Secreted.
Similarity:
Belongs to the IL-10 family.
SWISS:
Q9GZX6
Gene ID:
50616
Database links:
Entrez Gene: 50616 Human
Entrez Gene: 50929 Mouse
Entrez Gene: 500836 Rat
Omim: 605330 Human
SwissProt: Q9GZX6 Human
SwissProt: Q9JJY9 Mouse
Unigene: 287369 Human
Unigene: 103585 Mouse
Unigene: 195879 Rat
IL-22是白介素-10家族的成员,主要是由激活的T 淋巴细胞产生的一类重要的细胞因子,除了在Th17细胞中高表达之外，在NK和NKT等细胞中也有表达,在组织损伤修复以及牛皮癣、肝炎、肺炎、肠炎等慢性炎症中发挥重要作用.IL-22是继IL-6和IL-10之后又一个参与炎症反应和代谢调控的细胞因子，IL-22有可能成为干预脂肪肝发生发展的新方法。
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