This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Function:
This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the PUR DNA-binding protein family.
SWISS:
Q00577
Gene ID:
5813
Database links:
Entrez Gene: 5813 Human
Entrez Gene: 19290 Mouse
Entrez Gene: 307498 Rat
Omim: 600473 Human
SwissProt: Q00577 Human
SwissProt: P42669 Mouse
SwissProt: P86252 Rat
Unigene: 443121 Human
Unigene: 23362 Mouse
Unigene: 482241 Mouse
Unigene: 41055 Rat
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