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Rabbit Anti-FABP3/H-FABP antibody
Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epidermis (E-FABP, also designated psoriasis-associated FABP or PA-FABP), muscle and heart (H-FABP, also designated mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP), myelin (M-FABP) and testis (T-FABP). MDGI is highly expressed in the myocardium, skeletal and smooth muscle fibers, lipid and/or steroid synthesizing cells and terminally differentiated epithelia of the respiratory, intestinal and urogenital tracts.
Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
SWISS:
P05413
Gene ID:
2170
Database links:
Entrez Gene: 2170 Human
Entrez Gene: 14077 Mouse
Entrez Gene: 79131 Rat
SwissProt: P05413 Human
SwissProt: P11404 Mouse
SwissProt: P07483 Rat
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