Rabbit Anti-Claudin 3, 4, 6, 9 antibody

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pan-Claudin; Claudin 3 + 4 + 6 + 9; C7orf1; Claudin3; Claudin-3; CLDN 3; CLDN3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; CPETR 2; CPETR2; HRVP 1; HRVP1; Rat ventral prostate 1 like protein; CLD3_HUMAN; CLD4_HUMAN; CLD6_HUMAN

Cat:

SL2816R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Claudin 3, 4, 6, 9

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.

Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

DISEASE:
Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Similarity:
Belongs to the claudin family.

SWISS:
O15551

Gene ID:
1365

Database links:

Entrez Gene: 1365 Human

Entrez Gene: 12739 Mouse

Entrez Gene: 65130 Rat

Omim: 602910 Human

SwissProt: O15551 Human

SwissProt: Q9Z0G9 Mouse

SwissProt: Q63400 Rat

Unigene: 647023 Human

Unigene: 158662 Mouse

Unigene: 4513 Rat

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