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Rabbit Anti-Histone H1.0 antibody
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Function:
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
Subcellular Location:
Nucleus. Chromosome. The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
Post-translational modifications:
Phosphorylated on Ser-17 in RNA edited version.
Similarity:
Belongs to the histone H1/H5 family.
Contains 1 H15 (linker histone H1/H5 globular) domain.
SWISS:
P07305
Gene ID:
3005
Database links:
Entrez Gene: 3005 Human
Entrez Gene: 14958 Mouse
Entrez Gene: 24437 Rat
Omim: 142708 Human
SwissProt: P07305 Human
SwissProt: P10922 Mouse
SwissProt: P43278 Rat
Unigene: 745024 Human
Unigene: 24350 Mouse
Unigene: 3129 Rat
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