SLC16A11 (Solute Carrier Family 16 Member 11) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A7. Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.
Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in liver, salivary gland and thyroid.
DISEASE:
Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345).
Disease description:A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Similarity:
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
SWISS:
Q5NC32
Gene ID:
216867
Database links:
Entrez Gene: 162515 Human
Entrez Gene: 216867 Mouse
Entrez Gene: 287450 Rat
Omim: 615765 Human
SwissProt: Q8NCK7 Human
SwissProt: Q5NC32 Mouse
Unigene: 336564 Human
Unigene: 289238 Mouse
Unigene: 89414 Rat
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