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Rabbit Anti-Phospho-MKP1 (Ser296) antibody
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.
Function:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185'.
Tissue Specificity:
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain.
SWISS:
P28562
Gene ID:
1843
Database links:
Entrez Gene: 1843 Human
Entrez Gene: 19252 Mouse
Entrez Gene: 114856 Rat
Omim: 600714 Human
SwissProt: P28562 Human
SwissProt: P28563 Mouse
SwissProt: Q64623 Rat
Unigene: 171695 Human
Unigene: 239041 Mouse
Unigene: 98260 Rat
MKPs是一类丝氨酸/苏氨酸和酪氨酸双重底物特异性的磷酸酶 ,对于丝裂素活化蛋白激酶活性的调节起着十分重要的作用，可使丝裂素活化蛋白激酶上的苏氨酸/酪氨酸去磷酸化失活。目前研究发现MKPs分别有MKP-1、MKP-2、MKP-3及MKP4-6。
MKPs受MAPK信号通路中多种成分的诱导 ,决定了它与MAPK之间作用的特异性。 通过去磷酸化作用调节MAPK信号途径的活性 ,确保了细胞内信号的精确传递 ,参与了多种主要的细胞功能的调节。
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