NKX1-2 (NK1 Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is NKX1-1.
Function:
May function in cell specification, particularly in the CNS.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain.
Post-translational modifications:
Phosphorylated by HIPK2 in vitro.
Similarity:
Belongs to the NK-1 homeobox family.
Contains 1 homeobox DNA-binding domain.
SWISS:
P42580
Gene ID:
20231
Database links:
Entrez Gene: 390010 Human
Entrez Gene: 20231 Mouse
Entrez Gene: 293568 Rat
SwissProt: Q9UD57 Human
SwissProt: P42580 Mouse
Unigene: 334281 Mouse
Unigene: 389981 Mouse
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