FBXO18 belongs to the F-box protein family, whose members share the F-box, an approximately 40 amino acid motif. It has both DNA-dependent ATPase and DNA unwinding activities.
FBXO18 is a 1,043 amino acid protein encoded by the human gene FBXO18. FBXO18 belongs to the helicase family (UvrD subfamily) and contains one F-box domain. This nuclear protein is a DNA-dependent ATPase that unwinds double-stranded DNA in a 3' to 5' direction. FBXO18 also recognizes and binds to a variety of phosphorylated proteins and promotes their ubiquitination and degradation. It also interacts with Skp1 in the SCF E3 ubiquitin ligase complex consisting of Skp1, CUL-1, Rbx1 and FBXO18.
Function:
DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction.
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Subunit:
Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1.
Subcellular Location:
Nuclear
Similarity:
Belongs to the helicase family. UvrD subfamily.
Contains 1 F-box domain.
SWISS:
Q8NFZ0
Gene ID:
84893
Database links:
Entrez Gene: 84893 Human
GenBank: BC113377 Human
Omim: 607222 Human
SwissProt: Q8NFZ0 Human
Unigene: 498543 Human
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