Mouse Anti-CD34 antibody | Sunlong Medical

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CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN; Hematopoietic Stem Cell Marker; Endothelial Markers; Tumor biomarkers.bsm-16538M; bsm-41196M; bsm-41197M; bs-2038R; bs-0646R

Cat:

SLM10820M

Species Reactivity：

Human,Rat,

Immunogen：

Recombinant human CD34 :32-290/385<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Product Overview：

Protein: Jurkat(human) cell lysates at 30ug; Primary: Mouse Anti-human CD34 Monoclonal Antibody (SLM10820M, clone number: 2C1) at 1:500; Secondary: IRDye800CW Conjugated Goat (polyclonal) Anti-Mouse IgG(H+L) (SL40296G-IRDye8) at 1: 20000; Predicted band size : 39kDObserved band size : 115kD

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Hematopoietic Stem Cell Marker
Endothelial Markers
Tumor biomarkers

Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Post-translational modifications:
Highly glycosylated.
Phosphorylated on serine residues by PKC.

Similarity:
Belongs to the CD34 family.

SWISS:
P28906

Gene ID:
947

Database links:

Entrez Gene: 947 Human

Omim: 142230 Human

SwissProt: P28906 Human

Unigene: 374990 Human

造血干细胞标志物
内皮标志物
肿瘤生物标志物

细胞表面的唾液粘蛋白。 Picture

Protein: Jurkat(human) cell lysates at 30ug;
Primary: Mouse Anti-human CD34 Monoclonal Antibody (SLM10820M, clone number: 2C1) at 1:500;
Secondary: IRDye800CW Conjugated Goat (polyclonal) Anti-Mouse IgG(H+L) (SL40296G-IRDye8) at 1: 20000;
Predicted band size : 39kD
Observed band size : 115kD

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