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Home > Product > Antibody > Mouse Anti-human CD19/FITC antibody
CD19_HUMAN; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19; B-lymphocyte surface antigen B4; Leu 12; Leu12;
Cat:
SF00501
Species Reactivity：
(predicted: Human,)
Immunogen：
Recombinant human CD19 protein
Format：
Liquid
Storage instructions：
Store at 2-8℃. Protect from light. Avoid freezing.
Clonality：
Monoclonal
Isotype：
Mouse IgG1
Applications：
Flow Cyt=5ul/Test,Flow-Cyt=5ul/Testnot yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Mouse
Product Overview：
scatter diagram showing peripheral blood lymphocytes stained with SF00501. The cells were incubated with the antibody (SF00501, 5 µl/Test) for 30 min at 22°C. Acquisition of >10,000 events was performed.scatter diagram showing peripheral blood lymphocytes stained with SF00501. The cells were incubated with the antibody (SF00501, 5 µl/Test) for 30 min at 22°C. Acquisition of >10,000 events was performed.
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Unit:
Price: $
Product PDFs
Datasheet:


This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large SLCterminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]

SWISS:
P15391

Gene ID:
930

Picture

scatter diagram showing peripheral blood lymphocytes stained with SF00501. The cells were incubated with the antibody (SF00501, 5 µl/Test) for 30 min at 22°C. Acquisition of >10,000 events was performed.
scatter diagram showing peripheral blood lymphocytes stained with SF00501. The cells were incubated with the antibody (SF00501, 5 µl/Test) for 30 min at 22°C. Acquisition of >10,000 events was performed.
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