Mouse Anti-CD2 antibody | Sunlong Medical

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CD2_HUMAN; T-cell surface antigen CD2; T cell surface antigen CD2; SRBC; Erythrocyte receptor; LFA-2; LFA2; LFA3 receptor; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD 2; CD2 antigen; CD2 molecule;

Cat:

SLM33075M

Species Reactivity：

Human,Mouse,(predicted: Rat,)

Immunogen：

Recombinant human CD2 protein

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

Product Overview：

Paraformaldehyde-fixed, paraffin embedded (mouse spleen); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD2) Monoclonal Antibody, Unconjugated (SLM33075M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.Paraformaldehyde-fixed, paraffin embedded (mouse lymphoid); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD2) Monoclonal Antibody, Unconjugated (SLM33075M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]

Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Subunit:
Interacts with CD2AP. Interacts with PSTPIP1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

SWISS:
P06729

Gene ID:
914

Database links:

Entrez Gene: 914 Human

Entrez Gene: 12481 Mouse

Entrez Gene: 497761 Rat

Omim: 186990 Human

SwissProt: P06729 Human

SwissProt: P08920 Mouse

SwissProt: P08921 Rat

Unigene: 523500 Human

Unigene: 22842 Mouse

Unigene: 10328 Rat

CD2分子又称T11、绵羊红细胞受体（ER）、淋巴细胞功能相关抗原2（LFA-2）和Leu5，是人T淋巴细胞表面的单链糖蛋白.CD2分子是分布于胸腺细胞及所有成熟T淋巴细胞和大部分自然杀伤细胞表面的特征性分化抗原。CD2具有调节T淋巴细胞分化、成熟、激活和凋亡等功能，CD2与LFA-3之间的粘附功能对于T淋巴细胞TCR识别外来抗原与APC细胞表面MHC抗原复合物、肿瘤抗原、病毒感染靶细胞以及同种异体抗原均有重要的辅助作用。
最近研究表明，CD48和CD59也是CD2的配体，参与T细胞的粘附和细胞间的相互作用,此外，CD2可以与其它膜分子如CD44、CD45的功能有关。CD2具有对T细胞的旁路激活途径作用。 Picture

Paraformaldehyde-fixed, paraffin embedded (mouse lymphoid); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD2) Monoclonal Antibody, Unconjugated (SLM33075M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.

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