CD8 antigen, alpha polypeptide (p32); CD8a; CD8a antigen; CD8a molecule; CD8A_HUMAN; Leu2; Leu2 T lymphocyte antigen; MAL; OKT8 T cell antigen; p32; T cell antigen Leu2; T cell co receptor; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differe
Cat:
SLM30070M-PE
Species Reactivity：
Human,
Immunogen：
NULL
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Clonality：
Monoclonal
Isotype：
IgG1
Applications：
Flow-Cyt=20ul/Testnot yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Mouse
Product Overview：
Flow cytometry staining of normal human peripheral blood cells with CD8/PE(SLM30070M-PE)(Red histogram) or Mouse IgG1 Isotype Control (PE Conjugate)(C03-11002)(Blue histogram) . Total cells were used for analysis.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Subunit: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.
Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Flow cytometry staining of normal human peripheral blood cells with CD8/PE(SLM30070M-PE)(Red histogram) or Mouse IgG1 Isotype Control (PE Conjugate)(C03-11002
)(Blue histogram) . Total cells were used for analysis.
