Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Clonality：
Monoclonal
Isotype：
IgG1
Applications：
Flow-Cyt=20ul/Testnot yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Mouse
Product Overview：
Flow cytometry staining of normal human peripheral blood cells with CD38/FITC(SLM30080M-FITC)(Red histogram) or Mouse IgG2a Isotype Control (FITC Conjugate)(C03-2401)(Blue histogram) . Total cells were used for analysis.
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a SLCterminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Subcellular Location: Membrane; Single-pass type II membrane protein.
Tissue Specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Similarity: Belongs to the ADP-ribosyl cyclase family.
SWISS: P28907
Gene ID: 952
Database links:
Entrez Gene: 952 Human
Omim: 107270 Human
SwissProt: P28907 Human
Unigene: 479214 Human
Picture
Flow cytometry staining of normal human peripheral blood cells with CD38/FITC(SLM30080M-FITC)(Red histogram) or Mouse IgG2a Isotype Control (FITC Conjugate)(C03-2401)(Blue histogram) . Total cells were used for analysis.
