Store at 2-8℃. Protect from light. Avoid freezing.
Clonality:
Monoclonal
Isotype:
Mouse IgG1
Applications:
Flow Cyt=5ul/Test,Flow-Cyt=5ul/Testnot yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Mouse
Product Overview:
scatter diagram showing peripheral blood lymphocytes stained with SF00601. The cells were incubated with the antibody (SF00601, 5 µl/Test) for 30 min at 22°C. Acquisition of >10,000 events was performed.
The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
SWISS: P28906
Gene ID: 947
Picture
scatter diagram showing peripheral blood lymphocytes stained with SF00601. The cells were incubated with the antibody (SF00601, 5 µl/Test) for 30 min at 22°C. Acquisition of >10,000 events was performed.