Mouse Anti-BNP(H1G3) antibody

Home > Product > Antibody > Mouse Anti-BNP(H1G3) antibody

BNP 32; Brain natriuretic peptide 32; Gamma brain natriuretic peptide; Natriuretic peptide brain type; Natriuretic peptide precursor B; Natriuretic peptides B; NPPB; NPPB protein.

Cat:

SLM4579M

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human BNP

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Monoclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Mouse

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, SLCtype natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity.

Function:
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Subcellular Location:
Secreted.

Tissue Specificity:
Brain and also in atria, but at much lower levels than ANP.

Similarity:
Belongs to the natriuretic peptide family.

SWISS:
P16860

Gene ID:
4879

Database links:

Entrez Gene: 4879 Human

Omim: 600295 Human

SwissProt: P16860 Human

Unigene: 219140 Human

脑钠素主要是心脏激素，心脏作为内分泌器官释放脑钠素，调解体液及电解质内环境的恒定性。 B型利钠肽（钠尿肽）（B－typenatriureticpeptide，BNP），又称脑钠素或脑钠肽，因其有排钠利尿、内皮非依赖性的血管平滑肌作用而具有降压、抗心肌纤维化、影响神经内分泌系统等功效。近来发现BNP在各种心血管疾病，尤其是心室功能不全、急性心肌梗死（ami）、高血压等疾病的诊断、治疗及预后等方面有重要意义，已引起临床工作者的高度重视。

Product Feedback Wall