Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
Function:
Catalyzes the methylation of 5-carboxymethyl uridine to5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in tRNA. Catalyzes the last step in the formation of5-methylcarboxymethyl uridine at the wobble position of theanticodon loop in target tRNA. Has a preference for tRNA(Arg) andtRNA(Glu), and does not bind tRNA(Lys). Required for normalsurvival after DNA damage. May inhibit apoptosis and promote cellsurvival and angiogenesis.
Subunit:
Interacts with TRMT112.
Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantlycytoplasmic.
Tissue Specificity:
Widely expressed, with highest expression inspleen, followed by pancreas and lung.
Similarity:
Belongs to the alkB family.
Contains 1 Fe2OG dioxygenase domain.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q96BT7
Gene ID:
9361
Database links:
Entrez Gene: 9361 Human
Entrez Gene: 67667 Mouse
Entrez Gene: 366783 Rat
Omim: 613306 Human
SwissProt: Q96BT7 Human
SwissProt: Q80Y20 Mouse
Unigene: 503763 Human
Unigene: 116968 Mouse
Unigene: 88994 Mouse
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