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Mouse Anti-phospho-FXYD1 (Ser88) antibody
PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity.
Function:
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.
Post-translational modifications:
Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK (By similarity).
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.
Similarity:
Belongs to the FXYD family.
SWISS:
Q9Z239
Gene ID:
56188
Database links:
Entrez Gene: 476487 Dog
Entrez Gene: 5348 Human
Entrez Gene: 56188 Mouse
Entrez Gene: 58971 Rat
Omim: 602359 Human
SwissProt: P56513 Dog
SwissProt: O00168 Human
SwissProt: Q9Z239 Mouse
SwissProt: O08589 Rat
Unigene: 442498 Human
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