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Home > Product > Antibody > Mouse Anti-Cyclophilin B(Loading Control) antibody
Cphn 2; Cphn2; CyP 20b; CYP S1; CYP-S1; CYPB; MGC14109; MGC2224; peptidyl prolyl cis trans isomerase B; Peptidyl prolyl cis trans isomerase B precursor; Peptidyl-prolyl cis-trans isomerase B precursor; Peptidylprolyl isomerase B; PPIase; PPIB; Rotamase; S
Cat:
SLM33228M
Species Reactivity：
Human,Mouse,Rat,
Immunogen：
KLH conjugated synthetic peptide derived from human Cyclophilin B
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Monoclonal
Isotype：
IgG
Applications：
WB=1:500-1000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Mouse
Product Overview：
Sample: Lane 1: Hela (Human) Cell Lysate at 30 ugLane 2: A431 (Human) Cell Lysate at 30 ugLane 3: HepG2 (Human) Cell Lysate at 30 ugLane 4: Thyroid gland (Mouse) Lysate at 40 ugLane 5: Thyroid gland (Rat) Lysate at 40 ugLane 6: Placenta (Mouse) Lysate at 40 ugLane 7: Cerebrum (Mouse) Lysate at 40 ugLane 8: Cerebrum (Rat) Lysate at 40 ugLane 9: Liver (Mouse) Lysate at 40 ugLane 10: Liver (Rat) Lysate at 40 ugLane 11: Kidney (Mouse) Lysate at 40 ugLane 12: Kidney (Rat) Lysate at 40 ugLane 13: Huvec (Human) Cell Lysate at 30 ugLane 14: U937 (Human) Cell Lysate at 30 ugPrimary: Anti-Cyclophilin B (SLM33228M) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilutionPredicted band size: 20 kDObserved band size: 20 kD
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Unit:
Price: $
Product PDFs
Datasheet:


The cyclophilins are a conserved class of proteins that bind the immunosuppressive drug cyclosporin A (CsA) with high affinity. CsA blocks helper T-cell activation at a step between T-cell receptor stimulation and the transcriptional activation of cytokine genes. Cyclophilins from many species possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that is blocked by CsA and therefore may be relevant in CsA-mediated immunosuppression.

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

DISEASE:
Defects in PPIB are the cause of osteogenesis imperfect ype 9 (OI9) [MIM:25988]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.

Similarity:
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Contains 1 PPIase cyclophilin-type domain.

SWISS:
P23284

Gene ID:
5479

Database links:

Entrez Gene: 5479 Human

Entrez Gene: 19035 Mouse

Entrez Gene: 64367 Rat

Omim: 123841 Human

SwissProt: P23284 Human

SwissProt: P24369 Mouse

SwissProt: P24368 Rat

Unigene: 434937 Human

Unigene: 335249 Mouse

Unigene: 1893 Rat



Picture

Sample:
Lane 1: Hela (Human) Cell Lysate at 30 ug
Lane 2: A431 (Human) Cell Lysate at 30 ug
Lane 3: HepG2 (Human) Cell Lysate at 30 ug
Lane 4: Thyroid gland (Mouse) Lysate at 40 ug
Lane 5: Thyroid gland (Rat) Lysate at 40 ug
Lane 6: Placenta (Mouse) Lysate at 40 ug
Lane 7: Cerebrum (Mouse) Lysate at 40 ug
Lane 8: Cerebrum (Rat) Lysate at 40 ug
Lane 9: Liver (Mouse) Lysate at 40 ug
Lane 10: Liver (Rat) Lysate at 40 ug
Lane 11: Kidney (Mouse) Lysate at 40 ug
Lane 12: Kidney (Rat) Lysate at 40 ug
Lane 13: Huvec (Human) Cell Lysate at 30 ug
Lane 14: U937 (Human) Cell Lysate at 30 ug
Primary: Anti-Cyclophilin B (SLM33228M) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 20 kD
Observed band size: 20 kD
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